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Lastly, fungal laccases 19 , which have a broader substrate scope and higher redox potential than their bacterial counterparts, have been engineered for numerous industrial applications, including paper-pulp biobleaching, textile dye decolorization, bioremediation, food processing and biofuel cells 20

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Consequently, a small molecule targeting the Kelch domain of KEAP1 is highly likely to cross-react with the other proteins containing Kelch domains

These tools have gone from supporting roles to becoming essential parts of any successful clinical operation

Nature 2014;509:10509