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The pMET protein levels peak at P7P14 in the neocortex, a period corresponding to synaptogenesis and dendritic outgrowth, and are downregulated during the 3rd post-natal week, between P14 and P17, when pruning and functional synapse maturation occur (Eagleson et al., 2016)

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ARA-290 has the strongest specific evidence for SFN, with human clinical trials demonstrating measurable nerve fiber regrowth in the cornea of SFN patients

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