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This adaptive response is ancient biology working against modern goals

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For example, as LAT1 is involved in intestinal amino acid absorption, inhibition of LAT1 may disrupt this process, potentially leading to malnutrition (106)

High drug exposure leads to an increased risk of sinusoidal obstruction syndrome (SOS, an early complication of hematopoietic stem cell transplantation), whereas low drug exposure has been associated with a higher risk of disease recurrence and graft failure ( The aim of our study was therefore to identity gene polymorphisms involved in the metabolism of Cy and other drugs and correlate them with complications (GVHD, SOS, HC and TRM), after Haplo-HSCT