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This is because almost 70% of the entire immune system is located in the gut (Vighi G, 2008)

Annu Rev Immunol 25:139-70 Stuver R, Shah GL, Korde NS, Roeker LE, Mato AR, Batlevi CL, Chung DJ, Doddi S, Falchi L, Gyurkocza B (2022) Activity of AZD7442 (tixagevimab-cilgavimab) against Omicron SARS-CoV-2 in patients with hematologic malignancies

Santos-Silva AP, Andrade MN, Pereira-Rodrigues P et al (2018) Frontiers in endocrine disruption: impacts of organotin on the hypothalamus-pituitary-thyroid axis

The exception was bacteria belonging to Proteobacteria, where the content was similar in both cases

It helps a lot in some formulas and did very little in others (so the benefit really depends on the specific product)