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Reasons for the disparity in conclusions seem to be due to methodological discrepancies such as the testing protocols and the associated testretest reliability, dosing strategy (i.e., amount and timing), and the recent discovery of quality control issues with some manufacturers stated (i.e., citrulline:malate ratios)

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For example, Bunium persicum seed extract synergizes with vincristine (VCR), enhancing VCR-induced cytotoxicity in MCF-7 cells

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Ketamine infusions have been successfully administered off-label for a condition known as CRPS since the 1990s in both inpatient and outpatient settings, a highly relevant fact unfortunately left out of Pollacks article