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In addition to the impact of microbiota remodeling, microbiota metabolites can also directly or indirectly affect the hosts physiological functions [138]

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In another study evaluating the potential of Pinoresinol-4- O --d-glucopyranoside (Pgu) using the lithium/pilocarpine-induced rat model, seizure induction caused an increase in the levels of malondialdehyde (MDA) a marker of oxidative lipid damageand decreased catalase activity, while also increasing the expression levels of PTGS2, all of which was reversed by Pgu pretreatment, which also mitigated neurodegeneration 47

Bowers, 2001 enquadra toda a classe dos GHRP como secretagogos no mesmo recetor onde tambm atua a grelina endgena