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Botulinum toxin (Botox) injections are FDA-approved for cervical dystonia and spasticity from MS or stroke and are increasingly used for refractory back spasms and myofascial pain syndrome when other treatments have failed

This forms the highest part of the outer shoulder and is a bony area (see picture below)

Together, these chaperone systems constitute a multilayered defense network that buffers neurons against proteotoxic insults and delays disease progression

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645 However, the primary endpoint of improved SNCV was not met, and further studies remain uncertain