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once in solution, long-term stability typically decreases and becomes sequence-dependent

Firstly a few principles

Mutations in the hemoglobin beta (HBB) gene that result in reduced or complete ablation of -globin production lead to insufficient levels of functional hemoglobin

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Symptoms of FM were previously attributed to dysfunction in central nociceptive sensory processing [15], which was explained by altered pain perception in FM patients, generalized hypersensitivity to unpleasant stimuli, altered cognitive functions, and sleep disturbances [16]