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FIGURE 1 Promotion of Homeostasis of Redox The synthesis of reactive oxygen species (ROS) and antioxidant glutathione (GSH) is essential in maintaining the redox balance in our body ( Promotion of Cell Proliferation The phosphoinositide 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) [PIK3/AKT/mTOR] pathway is one of the keys signaling pathways involved in cell proliferation ( Regulation of Autophagy Autophagy is an important process of intracellular turnover that is evolutionarily conserved in eukaryotes

Milligan, E

This review delineates the multidimensional mechanisms compromising Treg fitness, highlighting the loss of FoxP3 stability, aberrant expression of immune checkpoints (e.g., TIGIT and PD-1), and the skewing of the Th17/Treg axis as critical intrinsic drivers