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Increasing evidence suggests that the primary mechanism behind BBB leakage after a stroke is the breakdown of the TJ complex

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Here, we show that positron emission tomography imaging with the system x c radiotracer, [ 18 F]FSPG, provides a sensitive and specific marker of NRF2 activation in orthotopic, patient-derived, and genetically engineered mouse models of NSCLC

[DOI] [PubMed] [Google Scholar] Lu SC, Bao Y, Huang ZZ, Sarthy VP, Kannan R

In detoxification pathway, a series of enzyme-catalyzed processes with broad specificities convert the toxic substances into less toxic metabolites by chemical reactions within the body