[0069] For example, to treat or ameliorate the effects of epilepsy, a subject may be administered an effective amount of one or more compounds or pharmaceutical compositions of the present disclosure and, e.g., one or more of the following: Albendazole, Banzel, BGG492 (Novartis Corp., New York, NY) Carbamazepine, Carbatrol, Clobazam, Clonazepam, Depakene, Depakote, Depakote ER, Diastat, Diazepam, Dilantin, Eslicarbazepine acetate, Ethosuximide, Ezogabine, Felbatol, Felbamate, Frisium, Gabapentin, Gabitril, Inovelon, JNJ-26489112 (Johnson and Johnson, New Brunswick, NJ) Keppra, Keppra XR, Klonopin, Lacosamide, Lamictal, Lamotrigine, Levetiracetam, Lorazepam, Luminal, Lyrica, Mysoline, Memantine, Neurontin, Onfi, Oxcarbazepine, Phenobarbital, Phenytek, Phenytoin, Potiga, Primidone, probenecid, PRX-00023 (EPIX Pharmaceuticals Inc, Lexington, MA), Rufinamide, Sabril, Tegretol, Tegretol XR, Tiagabine, Topamax, Topiramate, Trileptal, Valproic Acid, Vimpat, Zarontin, Zonegran, and Zonisamide
Primary outcome Improvement in verbal communication was significantly greater for the participants on folinic acid as compared with participants on placebo with a medium-to-large effect size (Cohens d =0.70) (Table 2A)
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Third, a single amino acid substitution at position 34 (lysine to arginine) prevents unwanted acylation at this position and enhances molecular stability
To date, 554 variants are described in Clinvar [83] (a public database of reports on the relationships among human variations and phenotypes) for ATP8B1 [84]
