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10.1016/j.jtemb.2024.127546 218 LiuH.ZhangX.ZhangM.ZhangS.LiJ.ZhangY.et al (2024b)

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Structural and biophysical studies using NMR and small-angle X-ray scattering have demonstrated that GSH directly participates in Fe-S cluster assembly, including formation of mitochondrial Fe-S biosynthetic complexes essential for respiratory chain function 204,205

This uncontrolled inflammation leads to overexposure to reactive oxygen species (ROS) derived from bacteria and/or the activated neutrophils, which in turn further amplifies the inflammation [52] and damages tissues