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10 (52.6%)), and altered sulfur pathways

However, preclinical successes were not successfully translated into early clinical trials (e.g., VNP20009) due to a critical immunogenicity-safety trade-off, in which the attenuation required to ensure safety compromised the ability to generate effective anti-tumor immunity

Its distinct mechanism makes it ideal for combination studies with GLP-1 agonists like Semaglutide exploring synergistic effects on appetite, glucose control, and energy balance that neither pathway achieves alone

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The rationale is mechanistic: BPC-157 and TB-500 appear to target complementary aspects of tissue repair