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The widespread pharmacotherapy of otherwise healthy populations with overweight or obesity with the goal of improving future health requires further regulatory and ethical consideration

Beyond the extensively studied NRF2 pathway, which has been developed as a therapeutic target [502, 503], the PI3K/AKT/mTOR signaling pathway also plays a crucial role in cell survival and metabolism

The maladaptive changes in the dopaminergic system further emphasize the role of neurotransmitter receptor remodeling in the development of mood disorders