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J Biol Chem 246:402411 Shug AL, Shrago E, Bittar N, Folts JD, Koke JR (1975) Acyl-CoA inhibition of adenine nucleotide translocation in ischemic myocardium

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This discrepancy highlights a key consideration for translational applications: while voluntary exercise naturally boosts irisin and may offer neuroprotective benefits, patients with neurodegenerative diseases such as Parkinsons often experience mobility limitations that restrict sustained physical activity 35