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Research shows that the amount of tryptophan in blood is decreased in PCS patients 30,31,32

Without sufficient glutathione, melanin regulation gets disrupted, leading to hyperpigmentation or uneven spots

Additionally, common side effects of general anesthesia such as hypoxia and hypotension, or poor oxygenation and low blood pressure, exacerbate the effect of these toxic agents on the body

As part of the IBD Ahead 2014 educational programme, a panel of IBD experts from 32 countries worldwide identified several prognostic factors for disease progression in CD, including ileal disease location, upper gastrointestinal involvement and extraintestinal manifestations, younger age or perianal disease at diagnosis, smoking, endoscopic severity, serologic reactivity to microbial antigens, and certain genetic mutations (e.g., NOD2)

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