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doi: 10.1128/IAI.69.7.4320-4328.2001 8 LuLLChungAWRosebrockTRGhebremichaelMYuWHGracePSet al

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To restore NAD + levels, ATM-deficient models were treated with NR, which stimulated PINK1-dependent mitophagy, reduced cytoplasmic DNA levels, and activated the NAD + -dependent SIRT1 signaling pathway, which in turn further promoted mitochondrial mitophagy and healthy morphology 111,288