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Topical glutathione: topical formulations are typically 1-2 % glutathione

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Glycogen Synthase Kinase-3 Inhibits the Xenobiotic and Antioxidant Cell Response by Direct Phosphorylation and Nuclear Exclusion of the Transcription Factor Nrf2

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(2) Metabolic pathway differences: certain microbial metabolites observed in animal models (such as specific indole derivatives) may differ in production levels and metabolic pathways in humans (52)