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For instance, BMSC-Exos enriched with irisin-a peptide derived from FNDC5-overexpressing cells-enhanced neuronal viability, suppressed ferroptosis, and improved functional recovery in ischemic stroke models [137]

In a recent clinical trial, treatment with a FGF21 analog, Pegbelfermin, reduces the hepatic fat fraction, as measured by MRI, in patients with NASH 40