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Ongoing investigations seek to fully characterize its effects and expand its applications in biomedical research

Expert Rev Neurother (2018) 18(7):57388

This would contradict the hypothesis of the role of peroxynitrite as the key oxidant in APAP pathophysiology and would also be inconsistent with the limited LPO

This culminates in a combined insult of oxidative stress, excessive autophagy, and inflammatory damage in the liver

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