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In conclusion, oxidative stress can be a possible explanation of hepatic damage induced by chronic therapy with chlorpheniramine maleate and cetirizine hydrochloride

Ishii S, Iizuka K, Miller BC, Uyeda K

doi: 10.1002/vms3.684 451 MandrichLEspositoAVCostaSCaputoE

Others experience fatigue, especially early in treatment when their caloric intake drops significantly

The comparatively higher sample size addresses biological variability, possible attrition and death rates (e.g., Doxorubicin toxicity), and type I error inflation in pairwise comparisons (Tukeys post-hoc test)