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Description

Collectively, ATRA-ATO-NPs offer a mechanistically targeted, systemically safe, and highly effective strategy for advanced oncotherapy through dual-site spatiotemporal and simultaneous Pin1 inhibition

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Cells were stained with 0.1 M MitoTracker Red CMXROS (Molecular Probes) and 4,6-diamidino-2-phenylindole (DAPI)

Through targeted delivery, this amplifies the anti-inflammatory efficacy of these molecules both at the ovarian and systemic levels and minimizes off-target effects [248, 249]