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Therapeutic B cell depletion impairs adaptive and autoreactive CD4+ T cell activation in mice

Interestingly, increased STAT3 signaling exerts a negative feedback response to the function of the JAK-STAT3 signaling pathways, i.e., STAT3 factor induces the expression of SOCS proteins which can interact with and inhibit the function of cytokine receptors and insulin/IGF-1 receptors (Figs