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Human Equivalent Dose Calculations Using standard conversion formulas accounting for body surface area differences between species, a rat oral dose of 0.0045 mg/lb translates to approximately 0.00073 mg/lb in humans, yielding roughly 0.112 mg/day for a 154-pound person

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The methionine synthase enzyme, which relies on B12 and Folate, is highly sensitive to oxidative stress and can become rapidly inactivated in an inflamed environment

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