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Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity

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By blocking NNMT, 5-amino-1MQ stimulates an increase in nicotinamide adenine dinucleotide (NAD+), a cofactor that is central to cellular metabolism, thereby increasing metabolic rate and activating a gene called sirtuin-1 (SIRT1)