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thermophilus CRISPR1, with PAM sequence NNAGAAW, may be identified by searching for 5'-N x -NNAGAAW-3' both on the input sequence and on the reverse-complement of the input

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IGF1 LR3 provides more direct receptor activation with fewer endocrine effects, though head-to-head comparisons are limited

This is also why a secretagogue approach is framed as "axis-friendly": because endogenous somatostatin is still in the loop, negative feedback is preserved, which in principle restrains the supraphysiologic IGF-1 spikes seen with exogenous GH