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2009 GSH and NO glutathione+and+nitric+oxide Vitamin D and GSH Also, VitD acted as an antioxidant factor by increasing GSH

Acknowledgements The authors research is funded by Instituto de Salud Carlos III (ISCIII)-Fondo de Investigacion Sanitaria (FIS)-Fondo Europeo de Desarrollo Regional FEDER (grants PI18/01366, PI21/00251, PI19/00588, P21/01453, PI18/01133, PI19/00815, PI22/00469, PI22/00050), European Research Area PerMed JTC2018 (KIDNEY ATTACK AC18/00064) and the RICORS programme to RICORS2040 (RD21/0005/0001), and also by Comunidad de Madrid en Biomedicina (grant P2022/BMD-7223, CIFRA_COR-CM)

Because we did not observe obvious differences of SLC13A3 expression between male and female human HCC tissues, we chose to use male mice for the present study

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NRF2 target genes also involve PPP products such as G6PD, 6PGD, transketolase, and transaldolase, indicating that NRF2 activation is crucial for participating in and/or maintaining the PPP, especially for producing NADPH to fuel FAS, TRX, and GSH systems 172