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Importantly, ALOX15 expression also correlated strongly with a T2 inflammatory gene signature (Supplemental Table 5), supporting the link between the GSH pathway, T2 inflammation, and 15LO1

In: Gill SS, Tuteja N, editors

These results validated that ZZW-115 worked efficiently in blocking the nuclear translocation of NUPR1 in our culture model and that inhibition of NUPR1 nuclear translocation induces cell death in phBECs, indicating an important protective role in bronchial epithelial cells