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Brindley and co-workers were the first to describe existence of two types of PAP based on their substrate specificity and sub-cellular localization 11

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The organism is capable of elaborating exotoxins that bind to receptors on intestinal epithelial cells, leading to inflammation and diarrhea.4 QT Prolongation Fluoroquinolones can cause arrhythmias due to QT prolonging effects that may be augmented if given together with any of the multiple other drugs, such as amiodarone, that cause QT prolongation