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/ Because the final phase of detoxification requires the removal of water-soluble complexes through the kidneys, staying properly hydrated is non-negotiable

& Gordon, J

In addition, Fe 2+ has also been proved to catalyze the nitrification process of ONOO to proteins such as MnSOD, which is beneficial to oxidative stress and mitochondrial dysfunction by APAP-mediated cell death [83, 84]