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Future studies are expected to elucidate the safety and efficacy of 5-amino-1MQ, identifying specific populations that may benefit or experience adverse effects

Experimental studies in neuropathic pain models suggest that tDCS exerts anti-inflammatory and neuroprotective effects, including the down-regulation of pro-inflammatory cytokines (e.g., TNF- , IL-1), the up-regulation of IL-10, and the suppression of microglial and astrocytic activation, thereby fostering adaptive plasticity and reducing hypersensitivity (85, 86)