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28 mTOR complexes associate with other proteins that are generally not considered part of the core, such as DEPTOR, an endogenous inhibitor of both mTOR complexes, and PRAS40, an endogenous inhibitor of mTORC1

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In the near future, the development of specific inhibitors targeting glutamine metabolism in cancer cells will be an ideal choice

Unfortunately, direct measurement of radical production in living cells is difficult because radicals are highly reactive and have a short half-life

JNK, c-Jun N-terminal Kinase