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Cystine transporter slc7a11/xCT in cancer: Ferroptosis, nutrient dependency, and cancer therapy

The latter can be reduced by thioredoxin (Trx) 2, which is further reduced by thioredoxin reductase [28]

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WTwild type

You want E2 within an optimal range (typically 20-40 pg/mL for men) where you can get its cognitive and cardiovascular benefits without mast cell hyperreactivity