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This is followed by multiple immune abnormalities: marked impairment of the immunosuppressive function of myeloid-derived suppressor cells (MDSCs), pro-inflammatory polarization of Kupffer cells, T-cell differentiation imbalance, and B-cell hyperactivation that induces antimitochondrial antibody (AMA)-mediated cytotoxicity

doi:10.2147/ CCID.S307013

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Deficiencies in vitamin B12 can lead to neurological complications, including peripheral neuropathy, cognitive decline, and psychiatric diseases such as depression and psychosis ( 8 Conclusion Deficiencies in complex B vitamins, particularly vitamins B9 (folate) and B12 (cobalamin), have significant neuropsychiatric manifestations that can profoundly impact mental and neurological health