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For LC-MS/MS analysis, 20 L of each plasma or urine sample was injected into a Sciex Exion LC AC system coupled with a SCIEX Triple TOF 5600 mass spectrometer (AB SCIEX, Canada)

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Chronic opioid use is associated with altered gut microbiota and predicts readmissions in patients with cirrhosis

Shringarpure R, Grune T, Sitte N, Davies KJ

If concomitant use of VYVANSE with other serotonergic drugs or CYP2D6 inhibitors is clinically warranted, initiate VYVANSE with lower doses, monitor patients for the emergence of serotonin syndrome during drug initiation or titration, and inform patients of the increased risk for serotonin syndrome