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Published online June 1, 2001 2,036 View 20 Download Abstract PDF BACKGROUND Free radical-mediated oxidative damage has been implicated in a variety of pathological processes such as diabetes mellitus, aging and atherosclerosis

Thus, the response to sugars seems to involve the cAMP/PKA pathway and to depend on Ca 2+ influx, while non-caloric sweeteners probably induce IP3-mediated Ca 2+ release from the stores (Bernhardt et al., 1996)