While this mechanism is highly effective in treating B-cell Acute Lymphoblastic Leukemia (B-ALL), it also triggers an abrupt release of inflammatory cytokines from activated T cells, predisposing patients to CRSparticularly during the initial days of therapy or in those with a high disease burden
Despite this relatively short half-life in circulation, the downstream metabolic effects persist for significantly longer due to the sustained activation of lipolytic enzymes and metabolic pathways initiated by the peptide
[DOI] [PMC free article] [PubMed] [Google Scholar] 258.Levy H., Raby B.A., Lake S., Tantisira K.G., Kwiatkowski D., Lazarus R., Silverman E.K., Richter B., Klimecki W.T., Vercelli D., et al
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