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The systemic hypotension associated with sepsis involves reflex vasoconstriction, which leads to a decrease in renal blood perfusion, ultimately resulting in ischemia and hypoxia in the kidney (87)

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Upon promoter binding, RSV polymerase experiences conformational changes including the stabilization of the supporting helix and the supporting loop as well as subtle inward movement of the PRNTase domain 35 , whereas there is no obvious overall structural remodeling of EBOV polymerase upon the association of the 3-leader 9

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