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66, 67 This might be particularly important since studies have reported higher tumor necrosis factor- in lymphocytes, 192 cerebrospinal fluid 193 and brains 194 of individuals with ASD as compared with controls

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First, in the cytosol, VPA is activated and links with reduced acetyl coenzyme A (CoA-SH) to form valproyl-CoA (by the ATP-dependent medium-chain acyl-CoA synthetase, located on the outer side of the mitochondrial membrane)