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13,14 Hematologists and hematopathologists frequently encounter patients with low B 12 levels that are found to have another cause for their macrocytosis with or without anemia (eg, hemolysis with reticulocytosis, drug-related macrocytosis, MDS, or other neoplasms)

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A similar approach known as protein misfolding cyclic amplification was used by Soto and colleagues 89