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Ohtsuki M, Okubo Y, Komine M, Imafuku S, Day RM, Chen P, Petric R, Maroli A, Nemoto O (2017) Apremilast, an oral phosphodiesterase 4 inhibitor, in the treatment of Japanese patients with moderate to severe plaque psoriasis: efficacy, safety and tolerability results from a phase 2b randomized controlled trial

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The oral forms do not function because glutathione gets digested and therefore cant work

Barton AR, Sherman MA, Mukamel RE, Loh P-R (2021) Whole-exome imputation within UK Biobank powers rare coding variant association and fine-mapping analyses

Similarly, for OLP lesions on the buccal mucosa, curcumin films provided continuous drug delivery, and patients found them easy to use without interfering with speech or eating (as they adhere until dissolved)