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PP2A can be deactivated by ROS which may in turn inhibit Akt/PKB

Free radical damage has been linked to chronic diseases, A Research suggests this effect applies to several types of cancer, Crocin, the main antioxidant in saffron, may also make cancer cells While these findings are promising, more research is needed to fully understand the anticancer effects of saffron

3.2 In vivo models Similar to other brain malignancies, the study of MB frequently relies on established cell lines, from murine and/or human origin, and PDX models