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The requirement for the homeostatic mechanism to be robust means that it must successfully prevent runaway synaptic dynamics across a broad range of input patterns and postsynaptic firing of electrophysiologically heterogeneous inhibitory neurons equipped with diverse plasticity mechanisms

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In summary, various forms and durations of exercise interventions exert multidimensional and sustained benefits targeting core impairments in patients with NDDs, including cognitive deficits, motor dysfunction, and reduced quality of life