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2022;119: e2201899119

With treatment of yohimbine in HFD rats, lipid peroxidation decreased when TST expression was elevated [95]

There remains some debate about their overall effectiveness

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Cells appear to be continually exposed to the threat of L-ROS-mediated destruction, as inhibition of GPX4 activity leads to the rapid accumulation of L-ROS and cell death in cell culture, and deletion of Gpx4 in mice is embryonic lethal [6, 39]