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Notably, ADA and PNP are essential targets involved in purine metabolic pathways

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107 had baseline FibroScan data, with mean kPa of 7.2 and CAP of 322

however, follicular cell hyperplasia can lead to false-positive results

Studies observed that gut bacteria produce metabolites such as lipopolysaccharides (LPS), and short-chain fatty acids (SCFAs) that are directly associated with the -synuclein aggregation process ( Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumonia, and Helicobacter pylori stimulate TLR4, triggering immune responses that lead to the production of pro-inflammatory cytokines, chemokines, and oxidative factors