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Endocrinology 141 : 26082613 Liu JL et al

Dietary Limitations: Many "fad" diets focus on extreme calorie reduction, which can slow metabolism over time and lead to nutrient deficiencies

B12 may lower homocysteine levels which could contribute to a lower odds of heart disease, but only in people who have a diagnosed B12 deficiency, Swenor says

This effect is thought to be mediated through GLP-1 receptors in the cardiovascular system and is generally not clinically significant, though patients with certain arrhythmias or those sensitive to heart rate changes should be monitored