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10.1111/j.1600-065X.2012.01158.x 272 RebsamenM.PochiniL.StasykT.De AraujoM

Le Henaff C, Mansouri R, Modrowski D et al (2015) Increased NF-B activity and decreased Wnt/-catenin signaling mediate reduced osteoblast differentiation and function in F508 cystic fibrosis transmembrane conductance regulator (CFTR) mice

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Preclinical studies have laid a foundation for understanding its regulatory potential, but the translational gap exposed by GDNF/NRTN clinical trials underscores the need for humility in assessing its clinical value

This approach not only induces cuproptosis but also increases PD-L1 expression, transforming cold tumors into hot tumors that respond to immunotherapy, significantly inhibiting tumor growth and activating a systemic anti-tumor immune response