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In summary, these studies indicated that the composition of phospholipids in biological membranes, especially the degree of unsaturation lipids in bilayer membranes, is key for determining the vulnerability of cells to ferroptosis

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however, ROS accumulation has a pro-proliferative and pro-survival role in FSLs

The 2,3-DPG conservation is particularly striking given its importance for functional and therapeutic success in the transfusion of stored RBCs, especially in critically ill patients with compromised vasculature 57