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Side effects, safety & contraindications In trials the most commonly reported side effects were gastrointestinal, including nausea, vomiting, constipation, and decreased appetite, generally described as dose-related and more frequent during dose escalation

In rabbit studies with 0.8 cm radial bone defects that remained incompletely healed in all control animals for 6 weeks, BPC-157 treatment (administered locally into the bone defect or intramuscularly) produced healing comparable to standard treatments including local bone marrow application or autologous cortical bone grafting

Classification-wise, BPC-157 is most accurately described as a synthetic peptide fragment rather than a hormone, growth factor, or receptor ligand of established class

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Animal welfare monitoring: During the 12-week experimental period, rats were monitored daily for general health status (e.g., activity, food/water intake, fur condition, presence of abnormal behaviors)