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We thank members of the Mizuno laboratory for many helpful discussions

Medicina 58 (2), 319

MMP, a key indicator of mitochondrial functionality, was assessed using JC-1 dye, which differentiates between energized and depolarized mitochondria

Mammalian Cells Cell culture Human embryonic kidney (HEK) cells were cultured in DMEM medium, containing 4.5 g/L glucose, 10 % FCS and 1 % penicillin/streptomycin, and cultivated at 37 C in a humidified atmosphere containing 5% CO 2

As confounding by indication is difficulty to control in FAERS analyses, an integrative approach to ADE detection and investigation is beneficial [81, 82]